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Multi-Organ Intervention State Space (MOISS): A Collision Geometry Framework for Quantifying Therapeutic Windows Across 10 Organ Systems in 301,470 ICU Patients

2026-02-09

Abstract excerpt

<h4>Background: </h4> Severity scoring systems such as SOFA, NEWS2, and qSOFA effectively identify deteriorating ICU patients by aggregating physiological parameters into composite indices that trigger clinical alerts. However, these systems evaluate patient state at discrete time points and do not model the temporal dynamics of organ deterioration or the pharmacokinetic constraints that govern whether a given int...

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Literature Corpus work
7cc3c4c6-58e2-5df9-8db2-5389349bc709
DOI
10.64898/2026.02.08.26345873
Open publication

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