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Article

Activation and inhibition of histone deacetylase 8 by monovalent cations.

The Journal of biological chemistry - 26 Feb 2010

Gantt Stephanie L, Joseph Caleb G, Fierke Carol A

Abstract excerpt

The metal-dependent histone deacetylases (HDACs) catalyze hydrolysis of acetyl groups from acetyllysine side chains and are targets of cancer therapeutics. Two bound monovalent cations (MVCs) of unknown function have been previously observed in crystal structures of HDAC8; site 1 is near the active site, whereas site 2 is located > 20 A from the catalytic metal ion. Here we demonstrate that one bound MVC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20029090
DOI: 10.1074/jbc.M109.033399
PMCID: PMC2825397

Genes

HDAC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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