Article

An Early Olfactory Transcriptomic Signature of Tauopathy: Gbp2b Emerges as a Candidate Biomarker of Tau-Driven Neuroinflammation

2025-07-04

Abstract excerpt

Olfactory dysfunction is increasingly recognized as an early feature of neurodegenerative diseases such as Alzheimer’s disease. PS19 mice, a well-established tauopathy model, exhibit hallmarks of tau pathology—including hyperphosphorylated tau and pretangle formations—in various regions of the olfactory system. Notably, very recent data demonstrated that aberrantly hyperphosphorylated tau (pTau) was detected as ea...

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Literature Corpus work: 7d0b6010-c76c-5f07-87f0-2fb36372055d
DOI: 10.1101/2025.07.01.662324

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