Article
Rye: genetic ancestry inference at biobank scale.
Nucleic acids research - 8 May 2023
Conley Andrew B, Rishishwar Lavanya, Ahmad Maria, Sharma Shivam, Norris Emily T, Jordan I King, Mariño-Ramírez Leonardo
Abstract excerpt
Biobank projects are generating genomic data for many thousands of individuals. Computational methods are needed to handle these massive data sets, including genetic ancestry (GA) inference tools. Current methods for GA inference do not scale to biobank-size genomic datasets. We present Rye-a new algorithm for GA inference at biobank scale. We compared the accuracy and runtime performance of Rye to the widely...
Topics
- Humans
- Genetics, Population
- Secale
- Biological Specimen Banks
- Algorithms
- Genomics
- Polymorphism, Single Nucleotide