Back to search

Article

Failure of Bacillus Calmette-Guérin Therapy in Patients with Bladder Cancer is Characterized by Immune Dysfunction Associated with Activator Protein 1

2026-05-10

Abstract excerpt

The standard-of-care for patients with higher-risk non-muscle invasive bladder cancer (NMIBC) after tumour resection is intravesical administration of Bacillus Calmette-Guérin (BCG). While this form of adjuvant immunotherapy has improved recurrence-free and progression-free survival, a large proportion of patients experience recurrences within a year of diagnosis. The reasons for this high rate of early recurrence...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7cf8b32e-cb5e-58cc-b2c6-e86c84b201bc
DOI
10.64898/2026.05.06.723215
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Failure of Bacillus Calmette-Guérin Therapy in Patients with Bladder Cancer is Characterized by Immune Dysfunction Associated with Activator Protein 1DOI 10.64898/2026.05.06.723215
Single Cell RNA-sequencing of BCG naïve and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM-mediated immune-suppressive pathwaySemantic proximity
B cell exhaustion associates with poor response to Bacillus Calmette-Guérin immunotherapy in patients with bladder cancerSemantic proximity
Comprehensive genome-wide association study into multiple recurrence and progression risk in non-muscle invasive bladder cancer.Semantic proximity
Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer.Semantic proximity
Elevated T-cell exhaustion and urinary tumor DNA levels are associated with BCG failure in patients with non-muscle invasive bladder cancerSemantic proximity
The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to TreatmentSemantic proximity
The urothelial transcriptomic response to interferon gamma predicts T1 recurrence-free and basal/squamous muscle-invasive bladder cancer survival and better targeted strategies for immune checkpoint blockingSemantic proximity
Increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages associate with poor clinical outcomes in BCG treated non-muscle invasive bladder cancerSemantic proximity
Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infectionsSemantic proximity
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomesSemantic proximity
Discovery of Molecular DNA Methylation-Based Biomarkers through Genome-Wide Analysis of Response Patterns to BCG for Bladder CancerSemantic proximity
The impact of single-nucleotide polymorphisms on intravesical recurrence after bacillus Calmette-Guérin therapy for non-muscle invasive bladder cancer in a genome-wide association study.Semantic proximity
Select a neighboring publication to make it the new centre.