Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer.

doi:10.1158/1078-0432.CCR-21-0205

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Article

Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non-Muscle-Invasive Bladder Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2021

Damrauer Jeffrey S, Roell Kyle R, Smith Markia A, Sun Xuezheng, Kirk Erin L, Hoadley Katherine A, Benefield Halei C, Iyer Gopakumar, Solit David B, Milowsky Matthew I, Kim William Y, Nielsen Matthew E, Wobker Sara E, Dalbagni Guido, Al-Ahmadie Hikmat A, Olshan Andrew F, Bochner Bernard H, Furberg Helena, Troester Melissa A, Pietzak Eugene J

Abstract excerpt

PURPOSE: Improved risk stratification and predictive biomarkers of treatment response are needed for non-muscle-invasive bladder cancer (NMIBC). Here we assessed the clinical utility of targeted RNA and DNA molecular profiling in NMIBC. EXPERIMENTAL DESIGN: Gene expression in NMIBC samples was profiled by NanoString nCounter, an RNA quantification platform, from two independent cohorts (n = 28, n = 50); targeted...

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Identifiers

PMID: 34117034
DOI: 10.1158/1078-0432.CCR-21-0205
PMCID: PMC8416390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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