Article

Rictor induces AKT signaling to regulate lymphatic valve formation

2023-06-13

Abstract excerpt

Lymphatic valves are specialized structures of the collecting lymphatic vessels and are crucial for preventing retrograde lymph flow. Mutations in valve-forming genes have been clinically implicated in the pathology of congenital lymphedema. Lymphatic valves form when oscillatory shear stress (OSS) from lymph flow signals through the PI3K/AKT pathway to promote the transcription of valve-forming genes that trigger...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7cdbdb88-e113-522c-9d63-8daaef677369
DOI: 10.1101/2023.06.12.544698

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rictor induces AKT signaling to regulate lymphatic valve formationDOI 10.1101/2023.06.12.544698Read

Rictor, an mTORC2 Protein, Regulates Murine Lymphatic Valve Formation Through the AKT-FOXO1 SignalingSemantic proximity Read

Mechanosensitive mTORC1 signaling maintains lymphatic valvesSemantic proximity Read

Foxo1 deletion promotes the growth of new lymphatic valvesSemantic proximity Read

FOXO1 represses lymphatic valve formation and maintenance via PRDM1Semantic proximity Read

CXCL12/CXCR4 Governs Lymphatic Valve Formation Through Flow Dependent AKT/FOXO1/FOXC2 ActivationSemantic proximity Read

Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenanceSemantic proximity Read

Lymphatic vessel development: fluid flow and valve-forming cells.Semantic proximity Read

S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ FormationSemantic proximity Read

Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic ExpansionSemantic proximity Read

The mechanosensory channel PIEZO1 functions upstream of angiopoietin/TIE/FOXO1 signaling in lymphatic developmentSemantic proximity Read

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.Semantic proximity Read

eNOS Regulates Lymphatic Valve Specification by Controlling β-Catenin Signaling During Embryogenesis in MiceSemantic proximity Read