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Article

Mechanosensitive mTORC1 signaling maintains lymphatic valves

24 Mar 2023

Abstract excerpt

Homeostatic maintenance and repair of lymphatic vessels are essential for health. We investigated the dynamics and the molecular mechanisms of lymphatic endothelial cell (LEC) renewal in adult mesenteric quiescent lymphatic vasculature using label-retention, lineage tracing, and cell ablation strategies. Unlike during development, adult LEC turnover and proliferation was confined to the valve regions of...

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PMID: 37036444
DOI: 10.1083/jcb.202207049

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