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Article

FOXO1 represses lymphatic valve formation and maintenance via PRDM1

1 Nov 2021

Abstract excerpt

Intraluminal lymphatic valves (LVs) contribute to the prevention of lymph backflow and maintain circulatory homeostasis. Several reports have investigated the molecular mechanisms which promote LV formation; however, the way in which they are suppressed is not completely clear. We show that the forkhead transcription factor FOXO1 is a suppressor of LV formation and maintenance in lymphatic endothelial cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34852224
DOI: 10.1016/j.celrep.2021.110048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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