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Article

Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion

15 Jun 2022

Abstract excerpt

BACKGROUND: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1) cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI calcium release-activated calcium modulator 1)-mediated mechanotransduction pathway that triggers lymphatic sprouting through Notch downregulation in response to fluid flow. However, the identity of its upstream mechanosensor remains unknown. This...

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PMID: 35701867
DOI: 10.1161/circresaha.121.320565

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