Article

Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences

2020-09-11

Abstract excerpt

<h4>SUMMARY</h4> Ribonuclease L (RNase L) is activated as part of the innate immune response and plays an important role in the clearance of viral infections. When activated, it endonucleolytically cleaves both viral and host RNAs, leading to a global reduction in protein synthesis. However, it remains unknown how widespread RNA decay, and consequent changes in the translatome, promote the elimination of viruses....

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Literature Corpus work: 264f1c53-0c01-5ad5-96d8-29ad987209e0
DOI: 10.1101/2020.09.10.291690

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