Article

Senolytic Treatment for Low Back Pain

2024-01-16

Abstract excerpt

Senescent cells (SnCs) accumulate due to aging and external cellular stress throughout the body. They adopt a senescence-associated secretory phenotype (SASP) and release inflammatory, and degenerative factors that actively contribute to age-related diseases such as low back pain (LBP). The senolytics, o-Vanillin and RG-7112, remove senescent human intervertebral (IVD) cells and reduce SASP release, but it is not...

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Literature Corpus work: 7cb771f1-828b-5cc2-ad87-13e4a0ee6c69
DOI: 10.1101/2024.01.15.575738

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