Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

2 Mar 2022

Abstract excerpt

Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP) produced by senescent cells is found to remodel extracellular matrix (ECM) metabolism and destruct homeostasis. Elimination of senescent cells by senolytics and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal surgery and disorders
Share to Spine and Intervertebral Disc Pathology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35309994
DOI: 10.3389/fbioe.2022.823945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc DegenerationPMID 35309994Read ↗

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and AgingSemantic proximity Read ↗

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degenerationSemantic proximity Read ↗

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironmentSemantic proximity Read ↗

[Research progress of cellular senescence and senescent secretary phenotype in intervertebral disc degeneration].Semantic proximity Read ↗

Senolytic Treatment for Low Back PainSemantic proximity Read ↗

Current senolytics: Mode of action, efficacy and limitations, and their future.Semantic proximity Read ↗

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.Semantic proximity Read ↗

Cellular Senescence: The Driving Force of Musculoskeletal DiseasesSemantic proximity Read ↗

Targeting cellular senescence with senotherapeutics: senolytics and senomorphicsSemantic proximity Read ↗

Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases.Semantic proximity Read ↗

Discovery, development, and future application of senolytics: theories and predictions.Semantic proximity Read ↗

The Potential Role and Therapeutic Relevance of Cellular Senescence in Skeletal PathophysiologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.