Article

Nanotransfer: Multi-Modal Detection and Spatial Mapping of Intercellular Horizontal DNA Transfer in Single-Cell and Spatial Genomics

2026-08-12

Abstract excerpt

<title>Abstract</title> <p>For a long time, we assumed somatic cells only pass DNA vertically during division. Recent work by Ly et al. [1] and Wu et al. [2] showed this rule breaks under heavy genomic stress: cells physically send intact DNA fragments, extrachromosomal circular DNA (ecDNA) oncogenes, and nuclear pieces to neighboring cells through thin tunneling nanotubes. Standard single-cell bioinformatic tool...

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Literature Corpus work: 7cb7164e-4582-5ad6-96a4-fb6ca61e8bb9
DOI: 10.21203/rs.3.rs-10667794/v1

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