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Exploration of RNA outside segmented cells in spatial transcriptomics reveals extrasomatic RNA organization

2025-12-09

Abstract excerpt

Image-based spatial transcriptomics (iST) enables visualization of RNA molecules in their spatial context, yet up to 40% of transcripts remains unassigned to cells and has been largely overlooked. In this study, we systematically analyze unassigned RNAs (uRNAs) across 14 public iST datasets and multiple technologies to characterize their nature and relevance in tissue biology. By assessing potential technical orig...

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Identifiers and source

Literature Corpus work
1be1dc18-63fd-5f9c-9f68-e39cbf12f757
DOI
10.64898/2025.12.07.692889
Open publication

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