Article

Image-Based Quantitative Single-Cell Method Suggests Increase of Global Chromatin Accessibility in Tumor Compared to Non-tumor Cell Lines

2024-09-06

Abstract excerpt

<h4>Summary</h4> The phenotypic plasticity of cancer cells has recently emerged as an important factor of treatment failure. The mechanisms of phenotypic plasticity are not fully understood. One of the hypotheses is that the degree of chromatin accessibility defines the easiness of cell transitions between different phenotypes. To test this, a method to compare overall chromatin accessibility between cells in a p...

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Literature Corpus work: 7cb4d49f-4848-58ec-9edc-d0e4cda1d41a
DOI: 10.1101/2024.09.05.611456

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