3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models.

doi:10.1186/2050-6511-14-11

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Article

3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models.

BMC pharmacology & toxicology - 11 Feb 2013

Gertych Arkadiusz, Oh Jin Ho, Wawrowsky Kolja A, Weisenberger Daniel J, Tajbakhsh Jian

Abstract excerpt

BACKGROUND: The spatial organization of the genome is being evaluated as a novel indicator of toxicity in conjunction with drug-induced global DNA hypomethylation and concurrent chromatin reorganization. 3D quantitative DNA methylation imaging (3D-qDMI) was applied as a cell-by-cell high-throughput approach to investigate this matter by assessing genome topology through represented immunofluorescent nuclear...

Topics

5-Methylcytosine
Antibodies, Monoclonal
Antineoplastic Agents
Apoptosis
Azacitidine
Cell Line, Tumor
Cell Survival
Cytidine
DNA Methylation
Humans
Liver Neoplasms
Male
Phenotype
Prostatic Neoplasms

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Identifiers

PMID: 23394161
DOI: 10.1186/2050-6511-14-11
PMCID: PMC3598242

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