Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The <i>Trypanosoma brucei</i> cAMP phosphodiesterases TbrPDEBl and TbrPDEB2: flagellar enzymes that are essential for parasite virulence

13 Dec 2006

Abstract excerpt

Cyclic nucleotide specific phosphodiesterases (PDEs) are pivotal regulators of cellular signaling. They are also important drug targets. Besides catalytic activity and substrate specificity, their subcellular localization and interaction with other cell components are also functionally important. In contrast to the mammalian PDEs, the significance of PDEs in protozoal pathogens remains mostly unknown. The genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phosphodiesterase function and regulation
Share to Signaling Pathways in Disease
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17167070
DOI: 10.1096/fj.06-6818com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The <i>Trypanosoma brucei</i> cAMP phosphodiesterases TbrPDEBl and TbrPDEB2: flagellar enzymes that are essential for parasite virulencePMID 17167070Read ↗

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in <i>T. brucei</i>Semantic proximity Read ↗

Cyclic AMP compartmentalization drives signal specificity to control vector colonization and mammalian host infection by American trypanosomesSemantic proximity Read ↗

The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!Semantic proximity Read ↗

Adenylate Cyclases of Trypanosoma brucei, Environmental Sensors and Controllers of Host Innate Immune ResponseSemantic proximity Read ↗

Downstream effectors of cyclic adenosine monophosphate signalling in Trypanosoma bruceiSemantic proximity Read ↗

Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei.Semantic proximity Read ↗

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma bruceiSemantic proximity Read ↗

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdASemantic proximity Read ↗

Cyclic nucleotide specific phosphodiesterases of Leishmania majorSemantic proximity Read ↗

Essential Bromodomain Tc BDF2 as a Drug Target against Chagas DiseaseSemantic proximity Read ↗

Phosphatidylinositol 4-kinase III-beta is required for Golgi maintenance and cytokinesis in Trypanosoma brucei.Semantic proximity Read ↗

Flagellar motility is required for the viability of the bloodstream trypanosome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.