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Article

Flagellar cAMP signaling controls trypanosome progression through host tissues

18 Feb 2019

Abstract excerpt

The unicellular parasite Trypanosoma brucei is transmitted between mammals by tsetse flies. Following the discovery that flagellar phosphodiesterase PDEB1 is required for trypanosomes to move in response to signals in vitro (social motility), we investigated its role in tsetse flies. Here we show that PDEB1 knockout parasites exhibit subtle changes in movement, reminiscent of bacterial chemotaxis mutants....

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PMID: 30778051
DOI: 10.1038/s41467-019-08696-y

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