Article
In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors.
Cell metabolism - 5 Dec 2017
Salamanca-Cardona Lucia, Shah Hardik, Poot Alex J, Correa Fabian M, Di Gialleonardo Valentina, Lui Hui, Miloushev Vesselin Z, Granlund Kristin L, Tee Sui S, Cross Justin R, Thompson Craig B, Keshari Kayvan R
Abstract excerpt
The oncometabolite 2-hydroxyglutarate (2-HG) is a signature biomarker in various cancers, where it accumulates as a result of mutations in isocitrate dehydrogenase (IDH). The metabolic source of 2-HG, in a wide variety of cancers, dictates both its generation and also potential therapeutic strategies, but this remains difficult to access in vivo. Here, utilizing patient-derived chondrosarcoma cells harboring...
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