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Article

D-2HG Inhibits Glutamine Synthetase Activity and Induces Senescence in IDH-Mutant Gliomas.

Aging and disease - 4 Aug 2025

Zhao Yuanlin, Shi Jiankuan, Yuan Yuan, Yang Ying, Gao Xing, Yang Risheng, Wang Yuying, Zhang Lijun, Li Jing, Hu Peizhen, Wang Yingmei, Sun Chao, Han Ruili, Xu Yuqiao, Li Zengshan, Wang Zhe, Gu Yu, Ye Jing

Abstract excerpt

IDH1/2 mutations are prevalent genetic alterations in gliomas that facilitate metabolic reprogramming and epigenetic modifications, which are essential for glioma progression. However, their exact contributions to tumorigenesis remain to be fully elucidated. Cellular senescence is a known precursor to tumorigenesis, and multiple oncogenes can initiate this senescence program. Our study demonstrated that the IDH1...

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Identifiers

PMID: 42552065
DOI: 10.14336/AD.2025.0554
PMCID: PMC13437120

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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