Article

In-Silico Stability Predictors: Investigation of Performance Towards balanced Experimental Data

2025-04-02

Abstract excerpt

Change in protein stability, quantified as the change in Gibbs free energy of folding (ΔΔG) in kcal/mol, plays a crucial role in functional alterations of proteins, with misfolding and destabilization commonly associated with pathogenicity. The past two decades have brought the development of bioinformatics tools leveraging evolutionary knowledge, empirical force fields, and machine learning to predict stability a...

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Literature Corpus work: 30e05ca0-150a-52f9-9fb9-46e6ad391ddd
DOI: 10.1101/2025.03.28.645695

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