Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE

11 Mar 2021

Abstract excerpt

Oncogene c-Myc (referred in this report as MYC) promotes tumorigenesis in multiple human cancers. MYC regulates numerous cellular programs involved in cell growth and cell metabolism. Tumor cells exhibit obligatory dependence on cholesterol metabolism, which provides essential membrane components and metabolites to support cell growth. To date, how cholesterol biosynthesis is delicately regulated to promote...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Cholesterol and Lipid Metabolism
Share to Metabolomics and Mass Spectrometry Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33791309
DOI: 10.3389/fcell.2021.655889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLEPMID 33791309Read ↗

SQLE-mediated squalene metabolism is critical for mitochondrial biogenesis and tumor development in K-ras-driven cancerSemantic proximity Read ↗

The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cellsSemantic proximity Read ↗

c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and DiseaseSemantic proximity Read ↗

Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression.Semantic proximity Read ↗

The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond.Semantic proximity Read ↗

The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signalingSemantic proximity Read ↗

A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization.Semantic proximity Read ↗

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and CancerSemantic proximity Read ↗

Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.Semantic proximity Read ↗

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptorSemantic proximity Read ↗

Cholesterol biosynthesis modulation regulates dengue viral replicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.