Reevaluating the Role of ACE Inhibitors in Skin Fibrosis Risk: Evidence from Mendelian Randomization

Abstract excerpt

<h4>Background</h4> Skin fibrosis, characterized by excessive extracellular matrix deposition, leads to hypertrophic scars and keloids, which are both common and often detrimental conditions. Angiotensin-converting enzyme (ACE) inhibitors have shown promise in animal studies and limited clinical trials for reducing scar formation. However, the causal relationship between ACE inhibition and skin fibrosis remains un...

Topics

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• Alanine
• Burns
• Cicatrix
• Genome-Wide Association Study
• Glycopeptides
• Mendelian Randomization Analysis
• Metabolomics
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

7c4ee6fb-073e-51af-888d-65315c3ec4d7

DOI

10.1101/2024.07.23.24310902