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Article

Skin microbiota, immune phenotypes, inflammatory response and hypertrophic scars: A Mendelian randomization study.

Burns : journal of the International Society for Burn Injuries - 1 Dec 2025

Li Yutang, Tang Li, He Yiyi, Li Yan, Yu Qinghua, Chen Xinxin, Yin Zhe, Zhen Dandan, Zhang XiuHang, Yu Jiaao

Abstract excerpt

BACKGROUND: There is emerging evidence of a link between skin microbiota and Hypertrophic scars (HS), but the specific causal relationships and the role of immune responses are unclear. METHODS: A genome-wide association study (GWAS) and Mendelian randomization (MR) analysis were used to explore the causal effects of skin microbiota, cytokines, and immune phenotypes on HS, with inverse variance weighting (IVW) as...

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PMID: 41092682
DOI: 10.1016/j.burns.2025.107705

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