Article

The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer

2019-11-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> After long-term androgen deprivation therapy, 25-30% prostate cancer (PCa) acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key transcription coactivator of the Hippo pathway, has been related to cancer progression. However, its role in neuroendocrine prostate cancer (NEPC) has not been assessed. <h4>METHODS</h4> Immunohistochemistry was used t...

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Literature Corpus work: c16fa5f6-8086-58f6-8b42-233732c20bf5
DOI: 10.1101/832360

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