Article
CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein.
Biochemical and biophysical research communications - 10 Mar 2006
Krick Roswitha, Aschrafi Amaz, Hasgün Dilek, Arnemann Joachim
Abstract excerpt
TSPY (testis-specific protein, Y-encoded) is a member of the greater SET/NAP family of molecules with various functions, e.g., in chromatin remodeling, regulation of gene expression, and has been implicated to play a role in the malignant development of gonadoblastoma, testicular and prostate cancer. Here we demonstrate that the C-terminus has a functional role for the nucleo-cytoplasmatic shuttling of the TSPY...
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