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Article

Up regulation of the Hippo signalling effector YAP1 is linked to early biochemical recurrence in prostate cancers

2 Jun 2020

Abstract excerpt

The transcriptional coactivator YAP1 controls the balance between cell proliferation and apoptosis. YAP1 overexpression is linked to poor prognosis in many cancer types, yet its role in prostate cancer is unknown. Here, we applied YAP1 immunohistochemistry to a tissue microarray containing 17,747 clinical prostate cancer specimens. Cytoplasmic and nuclear YAP1 staining was seen in 81% and 63% of tumours. For both...

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PMID: 32488048
DOI: 10.1038/s41598-020-65772-w

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Up regulation of the Hippo signalling effector YAP1 is linked to early biochemical recurrence in prostate cancersPMID 32488048Read ↗

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