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Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

1 Dec 2021

Abstract excerpt

The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of the human uterus and three-dimensional endometrial organoid cultures. We dissect the signaling pathways that determine cell fate of the epithelial lineages in the lumenal and glandular microenvironments. Our...

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PMID: 34857954
DOI: 10.1038/s41588-021-00972-2

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