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Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

5 Sept 2017

Abstract excerpt

Down syndrome (DS) caused by trisomy of chromosome 21 is the most common genetic cause of intellectual disability. Although the prenatal diagnosis of DS has become feasible, there are no therapies available for the rescue of DS-related neurocognitive impairment. A growth inducer newly identified in our screen of neural stem cells (NSCs) has potent inhibitory activity against dual-specificity tyrosine...

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PMID: 28874550
DOI: 10.1073/pnas.1704143114

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