Article

Anti-inflammatory and pro-proliferative effects of fasudil in human trisomy 21 neural progenitor cells

2026-03-20

Abstract excerpt

Down syndrome (DS) results from trisomy for human chromosome 21 and is the most frequent genetic cause of intellectual disability. No effective treatments currently exist that improve neurodevelopment and cognition. Atypical brain development in individuals with DS is apparent before birth, which suggests that the optimal time to begin administration of therapies is prenatally. Human neural progenitor cell (NPC) c...

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Literature Corpus work: 65856e69-9fc9-58a6-9b50-18a1cd6c5dbe
DOI: 10.64898/2026.03.19.712922

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