Article

Cell-type specific expression and behavioral impact of galanin and GalR1 in the locus coeruleus during opioid withdrawal

2021-02-01

Abstract excerpt

<h4>ABSTRACT</h4> The neuropeptide galanin is reported to attenuate opioid withdrawal symptoms, potentially by reducing neuronal hyperactivity in the noradrenergic locus coeruleus (LC) via galanin receptor 1 (GalR1). We evaluated this mechanism by using RNAscope in situ hybridization to characterize GalR1 mRNA distribution in the dorsal pons and to compare galanin and GalR1 mRNA expression in tyrosine hydroxylas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c060f0f-ebb8-5f18-89e2-2bbe2891efb6
DOI: 10.1101/2021.01.31.428998

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-type specific expression and behavioral impact of galanin and GalR1 in the locus coeruleus during opioid withdrawalDOI 10.1101/2021.01.31.428998Read

Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.Semantic proximity Read

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviorsSemantic proximity Read

The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.Semantic proximity Read

Chronic environmental or genetic elevation of galanin in noradrenergic neurons confers stress resilience in miceSemantic proximity Read

Opioid withdrawal engages a habenular subpopulation responsive to aversive statesSemantic proximity Read

Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine.Semantic proximity Read

Neuronal Correlates of Hyperalgesia and Somatic Signs of Heroin Withdrawal in Male and Female MiceSemantic proximity Read

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.Semantic proximity Read

Acute alcohol withdrawal is associated with c-Fos expression in the basal ganglia and associated circuitry: C57BL/6J and DBA/2J inbred mouse strain analyses.Semantic proximity Read

Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processing.Semantic proximity Read

Generation and phenotypic characterization of a galanin overexpressing mouse.Semantic proximity Read

Central amygdalar PKCδ neurons mediate fentanyl withdrawalSemantic proximity Read