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Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells

15 Aug 2018

Abstract excerpt

Somites (SMs) comprise a transient stem cell population that gives rise to multiple cell types, including dermatome (D), myotome (MYO), sclerotome (SCL) and syndetome (SYN) cells. Although several groups have reported induction protocols for MYO and SCL from pluripotent stem cells, no studies have demonstrated the induction of SYN and D from SMs. Here, we report systematic induction of these cells from human...

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PMID: 30139810
DOI: 10.1242/dev.165431

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