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Efficient in vivo anti-tumoral effect of the anti-CEA, granulysin-based immunotoxin MFE23GRNLY in a lung adenocarcinoma model. Combination with a Bcl-xL-selective BH3 mimetic

2025-06-04

Abstract excerpt

<title>Abstract</title> <p>MFE23GRNLY is an immunotoxin formed by the recombinant fusion of granulysin and the single chain fraction variable (scFv) of the anti-CEA antibody MFE23. Granulysin is a protein stored in the granules of human cytotoxic T lymphocytes (CTL) and NK cells with antimicrobial and antitumoral activity. Previous work from our group demonstrated that recombinant MFE23GRNLY preserves the cytotox...

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Literature Corpus work
7beae245-2f33-5e14-a625-0bd4c6c137de
DOI
10.21203/rs.3.rs-5446761/v1
Open publication

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Efficient in vivo anti-tumoral effect of the anti-CEA, granulysin-based immunotoxin MFE23GRNLY in a lung adenocarcinoma model. Combination with a Bcl-xL-selective BH3 mimeticDOI 10.21203/rs.3.rs-5446761/v1
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