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Granulysin Blocks Replication of Varicella-Zoster Virus and Triggers Apoptosis of Infected Cells

1 Jun 2001

Abstract excerpt

Granulysin, a lytic protein present in cytolytic granules of human natural killer and cytotoxic T cells, entered cells infected with varicella-zoster virus (VZV). Exposure to granulysin accelerated death of infected cells as assessed by apoptosis markers. The functional domain of granulysin that mediated its antiviral effects was amino acid 23-51; this domain also mediates the additional antitumor cell effects of...

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PMID: 11398808
DOI: 10.1089/088282401750234501

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