Article

Preclinical Studies of Granulysin-Based Anti-Tn Immunotoxins as A New Antitumoral Treatment

2022-03-01

Abstract excerpt

Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosilated MUC1, also known as the Tn antigen, expressed in a variety of tumor cell types. We first demonstrated the affinity of these immunotoxins for their antigen using surface plas...

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Literature Corpus work: 817c5f2e-174d-56b3-b4f2-07cf37603ae5
DOI: 10.20944/preprints202202.0268.v2

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