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Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia

30 Jul 2010

Abstract excerpt

The natural killer (NK) type of aggressive large granular lymphocytic (LGL) leukemia is a fatal illness that pursues a rapid clinical course. There are no effective therapies for this illness, and pathogenetic mechanisms remain undefined. Here we report that the survivin was highly expressed in both aggressive and chronic leukemic NK cells but not in normal NK cells. In vitro treatment of human and rat NK-LGL...

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PMID: 20671121
DOI: 10.1182/blood-2010-02-271080

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