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Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability

13 Dec 2023

Abstract excerpt

Abstract Background Glioblastoma (GBM) is the most malignant and invasive human brain tumor. Histone demethylase 4B (KDM4B) is abnormally expressed in GBM, but the molecular mechanisms by which KDM4B affects the malignant tumor progression are not well defined. Methods GBM cell lines and xenograft tumor samples were subjected to quantitative PCR (qPCR), Western blot, immunohistochemical staining (IHC), as well as...

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PMID: 38093312
DOI: 10.1186/s13148-023-01608-4

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