Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma

29 Apr 2015

Abstract excerpt

BACKGROUND: Epigenetic alterations, such as histone methylation, modulate Myc signaling, a pathway central to oncogenesis. We investigated the role of the histone demethylase KDM4B in N-Myc-mediated neuroblastoma pathogenesis. METHODS: Spearman correlation was performed to correlate MYCN and KDM4B expression. RNA interference, microarray analysis, gene set enrichment analysis, and real-time polymerase chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Epigenetics and DNA Methylation
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25925418
DOI: 10.1093/jnci/djv080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of Histone Demethylase KDM4B in Myc Signaling in NeuroblastomaPMID 25925418Read ↗

Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stabilitySemantic proximity Read ↗

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiationSemantic proximity Read ↗

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastomaSemantic proximity Read ↗

Epigenetic Dysregulation in MYCN-Amplified NeuroblastomaSemantic proximity Read ↗

KDM4A promotes the progression of neuroendocrine prostate cancerSemantic proximity Read ↗

KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neckSemantic proximity Read ↗

KDM2B overexpression correlates with poor prognosis and regulates glioma cell growthSemantic proximity Read ↗

Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cellsSemantic proximity Read ↗

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastomaSemantic proximity Read ↗

Targeting MYCN in Neuroblastoma by BET Bromodomain InhibitionSemantic proximity Read ↗

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in NeuroblastomaSemantic proximity Read ↗

Targeting MYCN-Driven Transcription By BET-Bromodomain InhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.