Article

Increased efficacy of histone methyltransferase G9a inhibitors against MYCN-amplified Neuroblastoma

2019-11-22

Abstract excerpt

Targeted inhibition of proteins modulating epigenetic changes is an increasingly important priority in cancer therapeutics, and many small molecule inhibitors are currently being developed. In the case of neuroblastoma (NB), a paediatric solid tumour with a paucity of intragenic mutations, epigenetic deregulation may be especially important. In this study we validate the histone methyltransferase G9a/EHMT2 as bein...

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Literature Corpus work: cb498d15-ede1-5f17-b8a8-78438972aa40
DOI: 10.1101/851105

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