Article

Biologically-informed Interpretable Deep Learning Framework for Phenotype Prediction and Gene Interaction Detection

2025-04-17

Abstract excerpt

The detection of epistatic effects has significant potential to enhance understanding of the genetic basis of complex traits, but statistical epistatic analysis methods are complex and labour intensive. In recent years, Deep Neural Networks (DNNs) have emerged as a powerful tool for modelling arbitrarily complex genetic interactions in relation to a phenotype; however, their utility is often limited by the challen...

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Literature Corpus work: 7bb581e4-77ce-51a7-8f79-e1288f3f839e
DOI: 10.1101/2025.04.11.648325

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