Article

Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer

2025-05-08

Abstract excerpt

Excess cholesterol is positively correlated with colorectal cancer (CRC). Current therapeutic strategies for modulating cholesterol levels in CRC are limited and often come with complications. Here, we demonstrated that microbiome shunting of intestinal cholesterol to anticancer metabolites is a safe and applicable therapeutic approach for CRC. By screening major microbial metabolic products of cholesterol, we fou...

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Identifiers and source

Literature Corpus work: 7ba416f9-0f1b-5f1c-b5f6-3008a9da9f90
DOI: 10.1101/2025.05.02.651972

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