Gut microbiota-derived queuine reprograms colon gene expression and alleviates colorectal cancer synergistically with Limosilactobacillus reuteri

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Colorectal cancer (CRC) is a multifactorial disease of the colorectal epithelium that could be driven by gut microbiota dysregulation, while the molecular mechanisms of microbial metabolitesin regulating CRC remain unclear. <bold>Results</bold> We aim to investigate the biological functions of gut microbiota-derived queuine in the host and the underlying mol...

Topics

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• Berberine and alkaloids research
• Cancer Cells and Metastasis
• Cancer, Lipids, and Metabolism
• Clostridium difficile and Clostridium perfringens research
• Gut microbiota and health
• Marine Sponges and Natural Products
• Mycobacterium research and diagnosis
• Pancreatic and Hepatic Oncology Research

Identifiers and source

Literature Corpus work

41ce746e-0ddb-5417-ae82-c58253a5fbbc

DOI

10.21203/rs.3.rs-7540054/v1