Lead Validation of the Olive Phenolic S-(-)-Oleocanthal for Effective Control of KRASG13D-Mutant Colorectal Cancer Progression and Metastasis.

doi:10.3390/nu18162623

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Article

Lead Validation of the Olive Phenolic S-(-)-Oleocanthal for Effective Control of KRASG13D-Mutant Colorectal Cancer Progression and Metastasis.

Nutrients - 11 Aug 2026

Tarun Md Towhidul Islam, Ebrahim Hassan Y, El Sayed Khalid A

Abstract excerpt

Background/Objectives: Colorectal cancer (CRC) is the second most common cancer-causing death in the United States. The Mediterranean diet, rich in extra-virgin olive oil (EVOO), is associated with a lower risk of colorectal cancer (CRC). Earlier studies reported S-(-)-oleocanthal (OC), the major EVOO phenolic, to be effective in CRC progression and recurrence suppression in a subcutaneous xenograft model by...

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