Article

Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres

2021-02-22

Abstract excerpt

Axon guidance is required for the establishment of brain circuits. Whether much of the molecular basis of axon guidance is known from animal models, the molecular machinery coordinating axon growth and pathfinding in humans remains to be elucidated. The use of induced pluripotent stem cells (iPSC) from human donors has revolutionized in vitro studies of the human brain. iPSC can be differentiated into neuronal st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b54f99a-cb66-52f1-9f20-94345090900f
DOI: 10.1101/2021.02.21.432144

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheresDOI 10.1101/2021.02.21.432144Read

A fast TMT-based proteomic workflow reveals neural enrichment in neurospheres of hiPSC-derived neural stem cellsSemantic proximity Read

Deciphering the protein dynamics and molecular determinants of iPSC-derived neuronsSemantic proximity Read

Proteome Complexity Scales with Architecture in Human Neural ModelsSemantic proximity Read

Phenotypic and Functional Characteristics of Human Schwann Cells as Revealed by Cell-Based Assays and RNA-SEQ.Semantic proximity Read

Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the ProteomeSemantic proximity Read

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs).Semantic proximity Read

Quantitative proteomic analysis identifies proteins and pathways related to neuronal development in differentiated SH-SY5Y neuroblastoma cellsSemantic proximity Read

Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.Semantic proximity Read

Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neuronsSemantic proximity Read

Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MSSemantic proximity Read

Multi-omic analysis of guided and unguided forebrain organoids reveal differences in cellular composition and metabolic profilesSemantic proximity Read

Temporal proteomic and PTMomic atlas of cerebral organoid developmentSemantic proximity Read