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Neuronal Differentiation of LUHMES Cells Induces Substantial Changes of the Proteome

20 Sept 2020

Abstract excerpt

Neuronal cell lines are important model systems to study mechanisms of neurodegenerative diseases. One example is the Lund Human Mesencephalic (LUHMES) cell line, which can differentiate into dopaminergic-like neurons and is frequently used to study mechanisms of Parkinson's disease and neurotoxicity. Neuronal differentiation of LUHMES cells is commonly verified with selected neuronal markers, but little is known...

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PMID: 32951307
DOI: 10.1002/pmic.202000174

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