Article

OPA1 mediates cardiac function and metabolism: in silico and in vivo evidence

2024-08-24

Abstract excerpt

OPA1 is an inner mitochondrial membrane protein that mediates diverse signaling processes. OPA1 is important for cardiac function and protects against cardiac insults such as ischemia reperfusion injury. We sought to further assess OPA1 in human and mouse cardiac pathologies, hypothesizing that OPA1 may also function in a protective manner in chronic heart failure. Bioinformatic analyses of histological and transc...

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Literature Corpus work: 45c8e889-9607-551b-a4b2-3a51b221f0e5
DOI: 10.1101/2024.08.23.605375

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