Article

The role of properdin in the pathogenesis of murine systemic lupus erythematosus

2019-01-01

Abstract excerpt

In systemic lupus erythematosus (SLE), complement-activating immune complexes (ICs) are central to the immunopathogenesis of disease. Their deposition in kidney initiates an inflammatory response resulting in glomerulonephritis. Properdin is the only known positive regulator of complement activation, but its role in SLE disease severity has not been studied yet. Properdin-deficient mice were crossed with MRL/lpr m...

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Literature Corpus work: 7b41120e-792c-552c-9940-1fce6b07a933
DOI: 10.25392/leicester.data.10330031.v1

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