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Article

Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2007

Spitzer Dirk, Mitchell Lynne M, Atkinson John P, Hourcade Dennis E

Abstract excerpt

Complement promotes the rapid recognition and elimination of pathogens, infected cells, and immune complexes. The biochemical basis for its target specificity is incompletely understood. In this report, we demonstrate that properdin can directly bind to microbial targets and provide a platform for the in situ assembly and function of the alternative pathway C3 convertases. This mechanism differs from the standard...

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Identifiers

PMID: 17675523
DOI: 10.4049/jimmunol.179.4.2600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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