Article
Characterization of mutant forms of recombinant human properdin lacking single thrombospondin type I repeats. Identification of modules important for function.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1995
Higgins J M, Wiedemann H, Timpl R, Reid K B
Abstract excerpt
Properdin is a serum glycoprotein that up-regulates the alternative pathway of complement by stabilizing the C3b-Bb complex. It also binds sulfated glycoconjugates, such as sulfatide, in vitro. Properdin is composed of cyclic dimers, trimers, and tetramers of a 53-kDa monomeric subunit. The monom...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Humans
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Properdin
- Sequence Alignment
- Thrombospondins
- Transfection